Nuno Mariz Weblog

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Guido van Rossum said in the latest FLOSS Weekly podcast:

My personal favorite — and I expect that that will remain a personal favorite for a long time — is something named Django. … I highly recommend it.

Django has been my tool for a new project of mine, has been worth it the time spent learning Django and Python(right now my personal favourite programming language).
Django preferred setup is Apache with mod_python, this has make my choice easier because I’ve been always using Apache with PHP.
If you want to give it a try(I recommend it), read the Part 1 of the tutorial.
And if you have doubts about performance, read this.