Guido van Rossum said in the latest FLOSS Weekly podcast:
My personal favorite -- and I expect that that will remain a personal favorite for a long time -- is something named Django. ... I highly recommend it.Django has been my tool for a new project of mine, has been worth it the time spent learning Django and Python(right now my personal favourite programming language). Django preferred setup is Apache with mod_python, this has make my choice easier because I've been always using Apache with PHP. If you want to give it a try(I recommend it), read the Part 1 of the tutorial. And if you have doubts about performance, read this.